Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mitochondrial mediation. Lucidenic acid B inhibits PMA-induced invasion of human hepatocellular carcinoma cells by inactivating the MAPK/ERK signaling pathway and decreasing the binding activity of NF-kappaB and AP-1. Lucidenic acid B had no effect on cell cycle and necrotic cells.

本研究探讨了从新型灵芝（G. lucidum YK-02）分离得到的杜鹃花酸（Lucidenic acids A, B, C, 和 N）对HL-60细胞诱导凋亡及凋亡途径的影响。结果显示，Lucidenic acid B（LAB）不影响细胞周期分布，但增加了早期和晚期凋亡细胞的数量，而不是坏死细胞数量。使用LAB处理HL-60细胞会导致线粒体膜电位的丧失。此外，LAB处理改变了凋亡促进与抑制蛋白Bcl-2家族成员的表达水平比例。LAB诱导的凋亡涉及线粒体细胞色素c的释放，并随后诱导caspase-9和caspase-3的激活，这些活动伴随着poly(ADP-ribose)聚合酶（PARP）的切割。